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Symptoms associated with serotonin syndrome may include the following combination of signs and symptomsmental status changese.gagitationhallucinationsdeliriumand comaautonomic instabilitye.gtachycardialabile blood pressuredizzinessdiaphoresisflushinghyperthermianeuromuscular symptomse.gtremorrigiditymyoclonushyperreflexiaincoordinationseizureswith or without gastrointestinal symptomse.gnauseavomitingdiarrheaPatients should be monitored for the emergence of serotonin syndromeespecially with concomitant use of ZOFRAN and other serotonergic drugsIf symptoms of serotonin syndrome occurdiscontinue ZOFRAN and initiate supportive treatmentPatients should be informed of the increased risk of serotonin syndromeespecially if ZOFRAN is used concomitantly with other serotonergic drugssee DRUG INTERACTIONSOVERDOSE
Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.
Carmustineetoposideand cisplatin do not affect the pharmacokinetics of ondansetron.
Then administer 4 mg three times a day for 1 to 2 days after completion of chemotherapy.
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in addition, postmarketing cases of torsade de pointes have been reported in patients using zofran.